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KMID : 0377619830450060411
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Korean Jungang Medical Journal
1983 Volume.45 No. 6 p.411 ~ p.416
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Evaluation of the Neuromuscular Blocking Effects of Pancuronium by "Train of four" and 1 Hz Stimulus
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Abstract
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There are many reports that pancuronium has various muscle blocking effect in man and animal. Despite an attempt to diminish the variation in responses to relaxants by standardizing experimental techniques such as anesthetic concentration kept constant, acid base status kept constant, pre medication omitted, and dosage calculated in terms of mg/kg, the marked variation was found to persist, and also stimuli frequency dependant response was suggested.
Therefore experimental study was performed by different stimulus frequency was applied to evaluate the neuromuscular blocking effect of pancuronium.
The experiment was performed on fourteen rabbits weighing 1.8 to 2.2 kg and these were divided into two groups; eight rabbits for 1 Hz group and six rabbits for Train of four group.
All animals were intubated through tracheostomy under general anesthesia with intraperitoneal urethane. Respiration was controlled by means of a Harvard animal respirator. The body temperature was kept at 35°C with a thermo-blanket.
The common peroneal nerve and anterior tibial muscle was exposed and the nerve stimulator was applied to the nerve muscle preparation.
The twitch height of the muscle contraction was recorded on a biophysiograph through the force displacement transducer. The common peroneal nerve was stimul-ated supramaximally by 1 Hz and Train of four. The degree of neuromuscular block following intravenous injection of pancuronium 0.03 mg/kg was measured in each group. The changes of the twitch height and the time of spontaneous recovery was compared in each group.
The results were as follows;
I. In 1 Hz group; full recovery of twitch height was observed in only half of the number of experimental animals(50%). Another half of the animals shown, maximal twitch height recovery was 66.6%, 68%, 70%, and 72%. Mean-while T, of Train of four response was shown 100% recovery.
2. In Train of four group; all animals shown 100% recovery of T4 and recovery index was 334.2 sec.
3. It is confirmed that Train of four method is more precise method than 1 Hz to evaluate the non-depolarizing muscle relaxants.
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